个人简介

张玉林 医学博士，主任医师，教授，博士生导师；首都医科大学附属北京佑安医院呼吸与危重症医学科主任；现任中国民族卫生协会培训部特邀专家。

专业擅长

擅长呼吸及各种呼吸感染/传染性疾病诊治，尤其注重疑难重症感染及艾滋病相关呼吸系统感染的临床诊治

学术成果

主持国家自然科学基金3项，主持及参与国家12.5-13.5传染病重大科技专项子课题4项，北京市自然科学基金1项；专利发明5项；第一/通讯作者发表SIC论文30余篇，累计影响因子100余分，参编中英文专著各1部；获得中华医学科技二等奖和北京市科技二等奖各1项。

1. Shan Y, Sun G, Ji J, Li Z, Chen X, Zhang X, Ma Y, Zhang Y, Zhang T* and Zhang Y*. Brain function abnormalities and neuroinflammation in people living with HIV-associated anxiety disorders. Front. Psychiatry 15: 1336233.

2. Zhang L, Cai M, Zhang X, Wang S, Pang L, Chen X, Zheng C, Sun Y, Liang Y, Guo S, Wei F*, Zhang Y*. Integrated analysis of microbiome and host transcriptome unveils correlations between lung microbiota and host immunity in bronchoalveolar lavage fluid of pneumocystis pneumonia patients. Microbes Infect. 2024 Jun 6:105374.

3. Liu P, Ben H, Guo J, Pang L, Liu N, Wang Y, Shi Y, Yang P, Gao Y, Guan Y, Lu S, Zhang Y*, Li B*, Chen D*. Highly sensitive single-molecule counting technology for cytokeratin 18 detection in non-alcoholic fatty liver disease using novel antibodies. Microchemical Journal.2024;198:0026-265X.

4. Chen X, Wei J, Li Z, Zhang Y, Zhang X, Zhang L, Wang X, Zhang Y*, Zhang T*. Dysregulation of Gut Microbiota-Derived Neuromodulatory Amino Acid Metabolism in Human Immunodeficiency Virus-Associated Neurocognitive Disorder: An Integrative Metagenomic and Metabolomic Analysis. Ann Neurol 2024 Aug;96(2):306-320.

5. Chen X, Wei J, Zhang Y, Zhang Y*, Zhang T*. Crosstalk between gut microbiome and neuroinflammation in pathogenesis of HIV-associated neurocognitive disorder. J Neurol Sci 2024 Feb 15:457:122889.

6. Zhang L, Cai M, Su B, Ma Y*, Zhang Y*. Mitochondrial Metabolism in Alveolar Macrophages of Patients Infected with HIV, Tuberculosis, and HIV/Tuberculosis. AIDS Res Hum Retroviruses. 2024 Mar;40(3):148-157.

7. Cui X, Chen F, Zhao J, Li D, Hu M, Chen X, Zhang Y*, Han L*. Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells. Sci Rep. 2023 Jan 23;13(1):1293.

8. Zhang X, Chen X, Zhang L, Sun Y, Liang Y, Li H, Zhang Y*. Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia. Neurochem Int. 2023 Nov 3; 171:105639.

9. Sun Y, Cai M, Liang Y, Zhang Y*. Disruption of blood-brain barrier: effects of HIV Tat on brain microvascular endothelial cells and tight junction proteins. J Neurovirol. 2023 Dec;29(6):658-668.5.

10. Zhao L, Wang Y, Chen X, Yang L, Cai M, Zhang Z, Zhang Y*, Ma Y*. Clinical characteristics of adult inpatients with Measles in Beijing from 2010 to 2021: a retrospective analysis. BMC Infect Dis. 2023 May 9;23(1):312.

11. Qiao L, Cui X, Jia L, Gao Y, Wang W, Wei F, Zhang Z, Chen D*, Ma Y*, Zhang Y*. Peripheral immune phenotypes and T cell receptor repertoire in pneumocystis pneumonia in HIV-1 infected patients. Clin Immunol. 2022 Apr; 237:108985.

12. Chen X, Jia L, Zhang X, Zhang T*, Zhang Y*. One arrow for two targets: potential co-treatment regimens for lymphoma and HIV. Blood Rev. 2022 Sep; 55:100965.

13. Zhang Y, Chen X, Jia L, Zhang Y*. Potential mechanism of SARS-CoV-2-associated central and peripheral nervous system impairment. Acta Neurol Scand. 2022 Sep;146(3):225-236.

14. Zhang Z, Zhang X, Chen X, Cui X, Cai M, Yang L, Zhang Y*. Clinical Features of Human Brucellosis and Risk Factors for Focal Complications: A Retrospective Analysis in a Tertiary-Care Hospital in Beijing, China. Int J Gen Med. 2022 Sep 19; 15:7373-7382.

15. Chen X, Ding W, Cui X, Wei J, Zhang Y, Zhang T*, Zhang Y*. HIV protease inhibitor attenuated astrocyte autophagy involvement in inflammation via p38 MAPK pathway, Antiviral Research, 2022, 208(105463).

16. Cui X, Wu Y, Jia L, Chang J, Li C, Guo C, Zhang T, Ma Y, Zhang Y*. A case of Castleman disease with hemophagocytic syndrome derived from HHV8 infection[J]. European journal of medical research, 2021, 26(1):119.

17. Chen X, Jia L, Wu Y, Chang J, Zhang T, Ma Y, Zhang Y*. A mass in the upper abdomen derived from Talaromyces marneffei infected lymphadenopathy: a case report[J]. BMC infectious diseases, 2021, 21(1):750.

18. Zhang Y, Gao Y, Qiao L, Wang W, Chen D. Inflammatory Response Cells During Acute Respiratory Distress Syndrome in Patients With Coronavirus Disease 2019 (COVID-19). Annals of internal medicine 2020; 173(5):402-404.

19. Wang S, Sun Y, Wang Y, Wang A, Kou B, Che Y, Chen D, Zhang Y*, Shi Y. ASPP2 inhibits hepatitis B virus replication by preventing nucleus translocation of HSF1 and attenuating the transactivation of ATG7[J]. J Cell Mol Med, 2021, 25(14):6899-908.

20. Yang Y, Cui X, Wei H, Guo C, Zhang Y*. Potential Anti-Coronavirus Agents and the Pharmacologic Mechanisms. Drug Des Devel Ther. 2021 Mar 17;15:1213-1223.

21. Chen X, Zhang T, Zhang Y*. Endoplasmic reticulum stress and autophagy in HIV-1-associated neurocognitive disorders. J Neurovirol. 2020 Dec;26(6):824-833.

22. Wu Y, Yang Y, Wei H, Jia L, Jiang T, Tian Y, Guo C, Zhang Y*. Mortality predictors among patients with HIV-associated pulmonary tuberculosis in Northeast China: A retrospective cohort analysis[J]. J Med Virol, 2021, 93(8):4901-07.

23. Zeng J, Zhang X, Jia L, Wu Y, Tian Y, Zhang Y*. Pretreatment lymphocyte-to-monocyte ratios predict AIDS-related diffuse large B-cell lymphoma overall survival. J Med Virol. 2021 Jun;93(6):3907-3914.

24. Yang Y, Liu H, Hua W, Guo C, Zhang Y*. Images of the month: Intrahepatic multiple low-signal lesions from Aeromonas salmonicida infection. Clin Med (Lond). 2020 Nov;20(6):e273-e274.

25. Wang B, Qiao L, Wang Y, et al. Mitochondrial DNA D-loop lesions with the enhancement of DNA repair contribute to gastrointestinal cancer progression[J]. Oncology reports, 2018, 40(6): 3694-3704.

26. Guo X, Wu J, Wei F, et al. Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study[J]. International journal of antimicrobial agents, 2018, 52(2): 201-209.

27. Gao Z, Shan J, Wang B, Qiao L, Chen D, Zhang Y*. DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner[J]. Molecular neurobiology, 2018, 55(3): 1988-1997.

28. Liang Q, Zeng J, Wu J, et al. Nucleoside reverse transcriptase inhibitors induced hepatocellular mitochondrial DNA lesions and compensatory enhancement of mitochondrial function and DNA repair[J]. International journal of antimicrobial agents, 2018, 51(3): 385-392.

29. Zeng J, Zhang X, Hua W, Guo C, Wu H, Jin R, Zhang Y*. Diffuse large B-cell lymphoma with pulmonary and cerebral involvement: A case report[J]. Mol Clin Oncol, 2018, 9(3):264-68.

30. Shi, Ying, Wang, Junwei, Wang, Yuhe, Wang, Anna, Guo, Hongliang, Wei, Feili，Mehta, Sanjay R.，Espitia, Stephen，Smith, Davey M.，Liu, Longgen，Zhang, Yulin*，Chen, Dexi. A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines[J]. Cancer Letters.2016.

31. Lai M, Zhang X, Li Q, Guo C, Zhang Y*. Fast-Growing Subcutaneous Tumors with Lower-Extremity Edema and Rib Lesions: A Case of Non-Hodgkin's Lymphoma in an HIV-1-Infected Patient[J]. Am J Case Rep, 2017, 18:1135-39.

32. Li A, Li Q, Guo C, Zhang Y*. Asymptomatic Meningitis and Lung Cavity in a Case of Cryptococcosis[J]. Am J Case Rep, 2017, 18:1140-44.

33. Liu, Zhiying，Zang, Yunjin，Qiao, Luxin，Liu, Kai，Ouyang, Yabo，Zhang, Yulin*，Chen, Dexi. ASPP2 involvement in p53-mediated HIV-1 envelope glycoprotein gp120 neurotoxicity in mice cerebrocortical neurons[J].Scientific Reports.2016.

34. Xu B, Liu H, Wang B, Zhang H, Wu H, Jin R, Zhang Y*. Fever, Dry Cough and Exertional Dyspnea: Pulmonary Lymphomatoid Granulomatosis Masquerading as Pneumonia, Granulomatosis with Polyangiitis and Infectious Mononucleosis[J]. Intern Med, 2015, 54(23):3045-9.

35. Zhang Y, Wang B, Liang Q, Qiao L, Xu B, Zhang H, Yang S, Chen J, Guo H, Wu J, Chen D. Mitochondrial DNA D-loop AG/TC transition mutation in cortical neurons of mice after long-term exposure to nucleoside analogues[J]. J Neurovirol, 2015, 21(5):500-7.

Zhang Y L, Ouyang Y B, Liu L G, et al. Blood-brain barrier and neuro-AIDS[J]. Eur Rev Med Pharmacol. 2015.